Management of HSE
The aim of treatment is to shorten the clinical course of disease, prevent complications and prevent the development of disease recurrence. Drug of choice is acyclovir, which is an antiviral substances that selectively inhibit replication of the virus without damaging normal cells by holding a competition with guanoside for viral DNA polymerase. Acyclovir is said to have the effect of minimum follow-up. The drug is excreted through the kidneys and the dosage should be reduced in patients with renal dysfunction.
The aim of treatment is to shorten the clinical course of disease, prevent complications and prevent the development of disease recurrence. Drug of choice is acyclovir, which is an antiviral substances that selectively inhibit replication of the virus without damaging normal cells by holding a competition with guanoside for viral DNA polymerase. Acyclovir is said to have the effect of minimum follow-up. The drug is excreted through the kidneys and the dosage should be reduced in patients with renal dysfunction.
If the maximum solubility of free acyclovir fraction exceeds the limit, there was a crystal that can induce the occurrence of nephropathy. Incidence of nephropathy risk factor is intravenous route of administration, giving the rapid infusion, dehydration, given together with other drug delivery is also nephrotoxic, renal disease as the basis of disease and too high doses. Risk of toxic can be avoided by performing adequately hydrated (eg, 1 cc of fluid per day per 1 mg of acyclovir is given every day). Due to the high PH generated, iv administration resulted in phlebitis and local inflammation in case of extravasation. Digestive disorders, headache and skin rashes are common as a side effect. Acyclovir can be used in pregnant women who experience severe infections.
Prevention HSEThere is no effective prevention for HSE. Transmission among the population is rare and prophylaxis therapy on the population in contact with patients and isolation of patients in particular are not required.
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HSE Complication and Prognosis