In the last 2 decades there is rapid development of antiviral drugs, but the Herpes Simplex Encephalitis (HSE) remains a severe disease with high morbidity and mortality.In children and adults, HSE found in temporal and frontal lobe and is caused by herpes simplex virus type 1 (HSV-1). In neonates, brain damage caused greater and is caused by HSV-2 are usually obtained at delivery. HSE must be distinguished from herpes simplex meningitis, caused by HSV-2 and is often associated with genital herpes infections that occur simultaneously.In the United States, the HSE is the cause of 10% of cases of encephalitis and is the most common cause of fatal encephalitis cases occurring sporadically and is estimated at 1 in 250,000 to 500,000 patients per year. The death rate without treatment ranges from 70%, while in cases with therapy, a mortality rate of 19% and> 50% of patients who survive have moderate to severe neurological deficits. The incidence among men and women in balance with the peak age at child's age and middle age
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Herpes Simplex Encephalitis Pathofisiology