Neonatal infection can be divided into 3 clinical types, namely: the spread of infection and generally attacks the liver, encephalitis and infections limited to skin, eyes and mouth. The first and second form often leads to death. Infections are usually caused by HSV 2 but infections caused by HSV1 is also common. The risk of infection in children depends on 2 main factors in the mother; the pad when the gestational age of pregnant women is generating HSV and depends also on whether the infection suffered by secondary infection or primary infection.
Only HSV excretion containing incurred during childbirth are dangerous for newborns with intrauterine infection although rare exceptions may occur. Primary infection in the mother can increase the risk of infection in infants from 3% to 30%, presumably because of immunity in the mother can provide protection.
Diagnosis is based on the cytological changes characteristic (multinucleated giant cell with intranuclear inclusions in tissue scrapings or biopsy), but must be confirmed by direct FA examination or by isolation of virus from lesions of oral or genital lesions or from brain biopsy in cases of encephalitis or with the finding of HSV DNA in the lesions or CSF fluid with PCR.Only HSV excretion containing incurred during childbirth are dangerous for newborns with intrauterine infection although rare exceptions may occur. Primary infection in the mother can increase the risk of infection in infants from 3% to 30%, presumably because of immunity in the mother can provide protection.
The diagnosis of primary infection is confirmed by the increase of 4 times the titer of paired sera by various serological tests; of specific immunoglobulin IgM for herpes lead to the suspect, but conclusive antibodies against primary infection. The techniques that can be relied upon to distinguish antibody type 1 and type 2 is now available in many diagnostic laboratories; virus isolates can be distinguished from the others by DNA analysis. Specific serological tests are not widely available.