Herpes Simplex Fact

Herpes simplex is a viral infection characterized by localized primary lesion, latency and the tendency for recurrence. There are 2 types of virus - the herpes simplex virus (HSV) types 1 and 2 in general lead to different clinical symptoms, depending on the entry road. Can attack the means of genital or oral mucosa. Primary infection with HSV-1 may be mild with no symptoms, occurred in early childhood.
Approximately 10% of primary infection, emerged as a disease with a diverse spectrum of clinical symptoms, characterized by hot and malaise to 1 week or more, may be accompanied by severe gingivostomatitis followed by a vesicular lesions on the oropharynx, severe keratoconjunctivitis, and accompanied by the emergence of symptoms and complications of chronic eczema-like skin, meningoencephalitis or some fatal infection that occurs in newborns (congenital herpes simplex, ICD-9 771.2, ICD-10 P35.2).

Herpes Zoster (shingles)

Herpes zoster (shingles) is a local manifestation of reactivation of latent varicella infection in the dorsal ganglia radix. Vesicular lesions appear as erythema limited basis in areas of skin, which follows the course of a single sensory nerve ganglia or group radix dorsalis. The lesions can appear in the form of an irregular bubble gang during the course of the nerve, usually unilateral. Vesicles located deeper and gather more closely than chicken pox, herpes zoster and varicella are histologically similar to each other. Almost always accompanied by pain and paresthesias once, and about 30% of adults who fell ill suffered from postherpetic neuralgia herpes. 

Herpes Simplex Encephalitis Complications and Prognosis

HSE  Complications
Seizures are common and some authors recommend prophylactic anti-seizure therapy in patients with severe HSE. Brain edema that occurs sometimes can be resolved with steroid therapy, although the use of steroids in the HSE is still a controversy. Adjunct therapy for brain edema include hyperventilation and barbiturates. Other complications that looks similar to all patients and patients with severe pain severe consciousness disturbance (eg, aspiration pneumonia, venous thrombosis profundus, and decubitus.)  

HSE  Prognosis

Herpes Simplex Encephalitis Therapy

Management of HSE
The aim of treatment is to shorten the clinical course of disease, prevent complications and prevent the development of disease recurrence. Drug of choice is acyclovir, which is an antiviral substances that selectively inhibit replication of the virus without damaging normal cells by holding a competition with guanoside for viral DNA polymerase. Acyclovir is said to have the effect of minimum follow-up. The drug is excreted through the kidneys and the dosage should be reduced in patients with renal dysfunction.

Radiological HSE Examination

HSE Radiological examination

MRI is an examination of selected, able to show pathologic changes are usually bilateral, in the medial temporal lobe and the inferior frontal lobe. The existence of lesions in the temporal lobe is significant HSE in the allegation.

Head CT scans can show changes in the temporal and frontal lobes, but less sensitive than MRI. In a third patient HSE found a normal head CT scan.
Other Examination